More than 150 Palestinians have been injured in clashes with Israeli police at the al-Aqsa Mosque compound in Jerusalem, Palestinian medics say.
Israeli police said officers entered the site after coming under attack with fireworks, stones and other objects.
Three Israeli police were hurt, they said.
The flashpoint site is deeply important to Muslims and Jews, who know it as the Temple Mount, and is at the heart of competing historical claims.
Israeli-Palestinian tensions have soared recently after deadly attacks in Israel and Palestinian deaths during subsequent Israeli raids in the occupied West Bank.
A 17-year-old Palestinian wounded on Thursday during an Israeli operation in the area of Jenin in the northern West Bank died on Friday, the Palestinian health ministry said.
More than 20 Palestinians, many identified as gunmen, have been killed since Israel stepped up sweeps in the West Bank, centring on Jenin district, after a Palestinian killed three Israelis in Tel Aviv last Thursday.
That attack was the fourth in Israel by Israeli Arabs and Palestinians in just over two weeks. The killings have left 12 Israelis and two Ukrainians dead, marking the deadliest period of attacks in Israel for more than 15 years and leaving the country on edge.