A Syrian anti-aircraft missile has exploded in southern Israel, only 30km (20 miles) from a secret nuclear site.
Warning sirens went off before a loud explosion was heard in the Dimona area. No injuries or damage were reported.
The Israeli military said the missile was one of several that had been fired towards an Israeli aircraft. It responded by attacking several air defence batteries in Syria.
Syria's military said Israeli missiles targeted sites around Damascus.
Most of the missiles were intercepted and downed, but four Syrian soldiers were injured and there was "some material damage", it added.
Israel frequently carries out strikes on Iran-linked targets in Syria, saying it will not tolerate what it considers Iranian military "entrenchment" in the country.